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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical for both murine hepatitis virus (MHV) and severe acute respiratory syndrome (SARS)-C...

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Literature Corpus work
d97d6b9a-65a8-5b68-927e-61a9db68fb4c
DOI
10.1101/2023.04.06.535927
Open publication

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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in miceDOI 10.1101/2023.04.06.535927
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