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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice

22 Aug 2023

Abstract excerpt

Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in these drug targets is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein encoded as a small domain at the N terminus of nonstructural protein 3. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical for both murine hepatitis virus...

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PMID: 37607224
DOI: 10.1073/pnas.2302083120

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