Article

WTAP-mediated epitranscriptomic program in alveolar macrophages confers prolonged protection against postinfluenza bacterial pneumonia

2026-05-27

Abstract excerpt

Secondary bacterial infections remain an intractable problem of seasonal influenza, primarily due to the depletion and defunctionalization of alveolar macrophages (AMs). Here, we described that N 6 -methyladenosine (m 6 A), the most prevalent RNA modification in eukaryotes, critically orchestrates trained immunity (TRIM) establishment in AMs. Influenza A virus (IAV)-trained AMs maintained low Wilms tumor 1-asso...

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Literature Corpus work: 4e9109eb-9ede-5c6c-adbd-aa93d85b232d
DOI: 10.64898/2026.05.23.727154

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