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Article

Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer.

Genes, chromosomes & cancer - 1 Jan 2018

Wang Xia, Teer Jamie K, Tousignant Renee N, Levin Albert M, Boulware David, Chitale Dhananjay A, Shaw Brandon M, Chen Zhihua, Zhang Yonghong, Blakeley Jaishri O, Acosta Maria T, Messiaen Ludwine M, Korf Bruce R, Tainsky Michael A

Abstract excerpt

NF1 mutations predispose to neurofibromatosis type 1 (NF1) and women with NF1 have a moderately elevated risk for breast cancer, especially under age 50. Germline genomic analysis may better define the risk so screening and prevention can be applied to the individuals who benefit the most. Survey conducted in several neurofibromatosis clinics in the United States has demonstrated a 17.2% lifetime risk of breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28891274
DOI: 10.1002/gcc.22503
PMCID: PMC7771338

Genes

ATM
BARD1
BRCA1
BRCA2
BRIP1
CDH1
CHEK2
FANCC
NBN
PALB2
PTEN
RAD50
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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