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Large-Scale Scoping Review of Chronic Stress-Induced Brain Changes via LLM-Powered Extraction of 9,585 Studies: BDNF Directional Inconsistency, Structural-Functional Dissociation, and the Neuroinflammation-HPA Crossover

2026-06-02

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : The effects of chronic stress on brain structure and function have been extensively studied, producing well-established narratives such as "stress reduces hippocampal BDNF" and "stress increases amygdala volume." However, these narratives are typically derived from qualitative reviews or small-scale meta-analyses. Whether they hold quantitatively across the...

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Literature Corpus work: 4e77ac5c-cdcb-5174-b6bf-daa5ed7ae483
DOI: 10.21203/rs.3.rs-9884522/v1

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Large-Scale Scoping Review of Chronic Stress-Induced Brain Changes via LLM-Powered Extraction of 9,585 Studies: BDNF Directional Inconsistency, Structural-Functional Dissociation, and the Neuroinflammation-HPA CrossoverDOI 10.21203/rs.3.rs-9884522/v1Read

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