Back to search

Article

Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortality

2019-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Suicidal behaviors are strongly linked with mood disorders, but the specific neurobiological and functional gene-expression correlates for this linkage remain elusive. We performed neuroimaging-guided RNA-sequencing in two studies to test the hypothesis that imaging-localized gray matter volume (GMV) loss in mood disorders, harbors gene-expression changes associated with disease morbidity and re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f0cf7f44-ec49-5ae9-a890-331d531a45f3
DOI
10.1101/762492
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortalityDOI 10.1101/762492
Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem studySemantic proximity
Functional Architecture of Brain and Blood Transcriptome Delineate Biological Continuity Between Suicidal Ideation and SuicideSemantic proximity
Transcription factor motifs associated with anterior insula gene-expression underlying mood disorder phenotypesSemantic proximity
Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals disorder-specific expression changes in major psychiatric disordersSemantic proximity
Genetically Informed Disassortative Brain Morphometric Similarities Revealing Suicide Risk in Bipolar Disorder.Semantic proximity
Cell-resolved cortical architecture and intercellular communication distinguish bipolar and major depressive disordersSemantic proximity
Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severitySemantic proximity
Brain network and blood transcriptomic correlations underpin psychopathological phenotypes: A Preliminary StudySemantic proximity
Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders.Semantic proximity
Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and geneticsSemantic proximity
Convergence of Brain Transcriptomic and Neuroimaging Patterns in Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder, and Major Depressive DisorderSemantic proximity
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.Semantic proximity
Select a neighboring publication to make it the new centre.