Article

A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence with Existing Human Data

2025-10-24

Abstract excerpt

<h4>Background</h4> Chronic stress is a major risk factor for psychiatric disorders, including anxiety, depression, and post-traumatic stress disorder. Chronic stress can cause structural alterations like grey matter atrophy in key emotion-related areas such as the prefrontal cortex (PFC). To identify biological pathways affected by chronic stress in the PFC, researchers have performed transcriptional profiling (...

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Literature Corpus work: 3df656fc-15c6-5bc9-a65c-01f5f9566073
DOI: 10.1101/2025.10.23.683091

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