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Article

MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data.

Nature genetics - 1 Jan 2026

Rossen Jordan, Shi Huwenbo, Strober Benjamin J, Zhang Martin Jinye, Kanai Masahiro, McCaw Zachary R, Liang Liming, Weissbrod Omer, Price Alkes L

Abstract excerpt

Leveraging multi-ancestry data can improve fine-mapping power. We propose MultiSuSiE, an extension of Sum of Single Effects (SuSiE), to multiple ancestries that allows causal effect sizes to vary across ancestries. We evaluated MultiSuSiE using whole-genome sequencing data from 47,000 African-ancestry, 36,000 Latino-ancestry and 116,000 European-ancestry individuals from All of Us. In simulations, MultiSuSiE...

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PMID: 41491094
DOI: 10.1038/s41588-025-02450-5
PMCID: PMC13091671

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