Article

SARS-CoV-2 variants from long-term, persistently infected immunocompromised patients have altered syncytia formation, temperature-dependent replication, and serum neutralizing antibody escape

2024-05-20

Abstract excerpt

SARS-CoV-2 infection of immunocompromised individuals often leads to prolonged detection of viral RNA and infectious virus in nasal specimens, presumably due to the lack of induction of an appropriate adaptive immune response. Mutations identified in virus sequences obtained from persistently infected patients bear signatures of immune evasion and have some overlap with sequences present in variants of concern. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e55d663-41de-5b7e-ad63-de528e680022
DOI: 10.1101/2024.05.18.594818

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 variants from long-term, persistently infected immunocompromised patients have altered syncytia formation, temperature-dependent replication, and serum neutralizing antibody escapeDOI 10.1101/2024.05.18.594818Read

Emergence of multiple SARS-CoV-2 mutations in an immunocompromised hostSemantic proximity Read

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised hostSemantic proximity Read

Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunitySemantic proximity Read

SARS-CoV-2 evolution and evasion from multiple antibody treatments in a cancer patientSemantic proximity Read

SARS-CoV-2 evolution during prolonged infection in immunocompromised patientsSemantic proximity Read

Virus Evolution in Prolonged Infections of Immunocompromised Individuals.Semantic proximity Read

Evidence of recurrent selection of mutations commonly found in SARS-CoV-2 variants of concern in viruses infecting immunocompromised patientsSemantic proximity Read

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.Semantic proximity Read

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series.Semantic proximity Read

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.Semantic proximity Read

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient: a source of immune escape variantsSemantic proximity Read

Combined Effects of Severe Immunocompromise and Prolonged Virus Shedding on Within-Host SARS-CoV-2 Evolution in COVID-19Semantic proximity Read