Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series.

doi:10.1016/j.ebiom.2021.103355

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series.

EBioMedicine - 1 May 2021

Truong Thao T, Ryutov Alex, Pandey Utsav, Yee Rebecca, Goldberg Lior, Bhojwani Deepa, Aguayo-Hiraldo Paibel, Pinsky Benjamin A, Pekosz Andrew, Shen Lishuang, Boyd Scott D, Wirz Oliver F, Röltgen Katharina, Bootwalla Moiz, Maglinte Dennis T, Ostrow Dejerianne, Ruble David, Han Jennifer H, Biegel Jaclyn A, Li Maggie, Huang ChunHong, Sahoo Malaya K, Pannaraj Pia S, O'Gorman Maurice, Judkins Alexander R, Gai Xiaowu, Dien Bard Jennifer

Abstract excerpt

BACKGROUND: There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses. METHODS: We describe three patients with acute lymphoblastic leukemia who were persistently positive for SARS-CoV-2 by real-time polymerase chain reaction. Viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Immune Evasion

Share to Immunity, Humoral

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to SARS-CoV-2

Share to Sequence Analysis, RNA

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 33915337
DOI: 10.1016/j.ebiom.2021.103355
PMCID: PMC8072072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series.PMID 33915337Read ↗

Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunitySemantic proximity Read ↗

SARS-CoV-2 shedding, infectivity and evolution in an immunocompromised adult patientSemantic proximity Read ↗

COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report.Semantic proximity Read ↗

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised hostSemantic proximity Read ↗

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.Semantic proximity Read ↗

Molecular Characterization of Persistent SARS-CoV-2 Infections in Immunocompromised Patients.Semantic proximity Read ↗

Emergence of multiple SARS-CoV-2 mutations in an immunocompromised hostSemantic proximity Read ↗

SARS-CoV-2 evolution during prolonged infection in immunocompromised patientsSemantic proximity Read ↗

SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.Semantic proximity Read ↗

Prolonged Infectious SARS-CoV-2 Shedding from an Immunocompromised PatientSemantic proximity Read ↗

Case reports of persistent SARS-CoV-2 infection outline within-host viral evolution in immunocompromised patients.Semantic proximity Read ↗

SARS-CoV-2 variants from long-term, persistently infected immunocompromised patients have altered syncytia formation, temperature-dependent replication, and serum neutralizing antibody escapeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.