Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.

doi:10.1038/s41467-021-26602-3

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Article

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.

Nature communications - 4 Nov 2021

Weigang Sebastian, Fuchs Jonas, Zimmer Gert, Schnepf Daniel, Kern Lisa, Beer Julius, Luxenburger Hendrik, Ankerhold Jakob, Falcone Valeria, Kemming Janine, Hofmann Maike, Thimme Robert, Neumann-Haefelin Christoph, Ulferts Svenja, Grosse Robert, Hornuss Daniel, Tanriver Yakup, Rieg Siegbert, Wagner Dirk, Huzly Daniela, Schwemmle Martin, Panning Marcus, Kochs Georg

Abstract excerpt

The origin of SARS-CoV-2 variants of concern remains unclear. Here, we test whether intra-host virus evolution during persistent infections could be a contributing factor by characterizing the long-term SARS-CoV-2 infection dynamics in an immunosuppressed kidney transplant recipient. Applying RT-qPCR and next-generation sequencing (NGS) of sequential respiratory specimens, we identify several mutations in the...

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Identifiers

PMID: 34737266
DOI: 10.1038/s41467-021-26602-3
PMCID: PMC8568958

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