Article

Global changes of 5-hydroxymethylcytosine and 5-methylcytosine from normal to tumor tissues are associated with carcinogenesis and prognosis in colorectal cancer*

2017-09-01

Abstract excerpt

Aberrant DNA methylation has raised widespread attention in tumorigenesis. In this study, we aimed to investigate the changes of global DNA methylation and hydroxymethylation from normal to tumor tissues in colorectal cancer (CRC) and their association with the prognosis. The levels of genomic 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) in cancerous tissues were significantly lower than those in corr...

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Identifiers and source

Literature Corpus work: 4e4f4a45-506c-5b15-bb09-1eb92dd065f3
DOI: 10.1631/jzus.b1600314
PMCID: PMC5611546

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