Article

Pareto Optimality Reveals an Atlas of Cellular Archetypes

2024-12-04

Abstract excerpt

We sought to discover universal organizing principles behind phenotypic variation within cell types. Pareto optimality describes how trade-offs between optimal solutions account for variation, predicting that the boundary points of a data distribution reflect specialized functions. We hypothesized that Pareto optimality dominates transcriptomic variation across all cell types. We used the Tabula Sapiens atlas of s...

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Literature Corpus work: 4e3af21c-569a-5b43-9417-03fc10b53024
DOI: 10.1101/2024.12.04.626890

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