Article
Tumor diversity and the trade-off between universal cancer tasks.
Nature communications - 28 Nov 2019
Hausser Jean, Szekely Pablo, Bar Noam, Zimmer Anat, Sheftel Hila, Caldas Carlos, Alon Uri
Abstract excerpt
Recent advances have enabled powerful methods to sort tumors into prognosis and treatment groups. We are still missing, however, a general theoretical framework to understand the vast diversity of tumor gene expression and mutations. Here we present a framework based on multi-task evolution theory, using the fact that tumors need to perform multiple tasks that contribute to their fitness. We find that trade-offs...
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