Geometric quantification of cell phenotype transition manifolds with information geometry.

Abstract excerpt

Cell phenotype transition (CPT) is crucial in development and other biological processes. Advances in single-cell sequencing reveal that CPT dynamics are confined to low-dimensional manifolds, yet current methods cannot directly quantify these manifolds. We present SCIM (single-cell information manifolds), a geometry-guided approach using information geometry. SCIM embeds single-cell gene expression profiles as...

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