Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type

Abstract excerpt

Single-cell gene expression reveals the diversity within a differentiated cell type. Often, cells of the same type show a continuum of gene-expression patterns. The origin of such continuum gene-expression patterns is unclear. To address this, we develop a theory to understand how a continuum provides division of labor in a tissue in which cells collectively contribute to several tasks. We find that a continuum...

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