Article

Gene-First Identity Construction for Robust Cell Identification in Single-Cell Transcriptomics

2026-02-26

Abstract excerpt

The precise delineation of cell types is fundamental to single-cell transcriptomics, yet current clustering pipelines often violate an axiomatic principle: hierarchical consistency. Existing methods measure cell-to-cell distances within a fixed global feature space, disregarding the fact that biological distinctions are inherently context-dependent lineage separation requires different gene programs than subtype r...

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Literature Corpus work: 7777df9c-d51a-51f1-be4f-c82911a74127
DOI: 10.64898/2026.02.25.707869

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