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Article

Osteopontin aggravates myocardial fibrosis by promoting phenotypic transition of cardiac fibroblasts via Hippo-YAP pathway.

Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2026

Liu Chen, Liu Wentao, Wang Yuan, Jiang Chengzhi, Chen Sheng, Huang Qianqian, Xiong Xiaowei, Wang Li, Zeng Guohua, Huang Qiren

Abstract excerpt

Osteopontin (OPN), a glycosylated protein ubiquitously in cellular matrix, exhibits a low expression in normal myocardial tissue but a high expression in fibrotic myocardial tissue. However, the action and mechanisms of OPN on the pathogenesis of myocardial fibrosis (MF) remain unclear. The purpose of the study is to investigate the action and mechanisms of OPN on the occurrence and development of MF, emphasizing...

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Identifiers

PMID: 41478364
DOI: 10.1016/j.bbadis.2025.168150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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