Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-Inducible Factor 2α: A Novel Target in Gliomas

9 Aug 2018

Abstract excerpt

Hypoxia is an important contributor to aggressive behavior and resistance mechanisms in glioblastoma. Upregulation of hypoxia inducible transcription factors (HIFs) is the primary adaptive cellular response to a hypoxic environment. While HIF1α has been widely studied in cancer, HIF2α offers a potentially more specific and appealing target in glioblastoma given expression in glioma stem cells and not normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30089425
DOI: 10.4155/fmc-2018-0163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-Inducible Factor 2α: A Novel Target in GliomasPMID 30089425Read ↗

Role of hypoxia-inducible factor-1α as a cancer therapy targetSemantic proximity Read ↗

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discoverySemantic proximity Read ↗

Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiformeSemantic proximity Read ↗

Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistanceSemantic proximity Read ↗

Hypoxia-inducible factors: central regulators of the tumor phenotype.Semantic proximity Read ↗

Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastomaSemantic proximity Read ↗

Glioblastoma Stem Cells as a New Therapeutic Target for GlioblastomaSemantic proximity Read ↗

Hypoxia-inducible factors: cancer progression and clinical translationSemantic proximity Read ↗

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunitySemantic proximity Read ↗

The diagnostic and prognositic significances of HIF1A in glioma patients, a meta-analysis and bioinformatics approachSemantic proximity Read ↗

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapySemantic proximity Read ↗

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2αSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.