Rapamycin extends murine lifespan but has limited effects on aging.

doi:10.1172/JCI67674

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Rapamycin extends murine lifespan but has limited effects on aging.

The Journal of clinical investigation - 1 Aug 2013

Neff Frauke, Flores-Dominguez Diana, Ryan Devon P, Horsch Marion, Schröder Susanne, Adler Thure, Afonso Luciana Caminha, Aguilar-Pimentel Juan Antonio, Becker Lore, Garrett Lillian, Hans Wolfgang, Hettich Moritz M, Holtmeier Richard, Hölter Sabine M, Moreth Kristin, Prehn Cornelia, Puk Oliver, Rácz Ildikó, Rathkolb Birgit, Rozman Jan, Naton Beatrix, Ordemann Rainer, Adamski Jerzy, Beckers Johannes, Bekeredjian Raffi, Busch Dirk H, Ehninger Gerhard, Graw Jochen, Höfler Heinz, Klingenspor Martin, Klopstock Thomas, Ollert Markus, Stypmann Jörg, Wolf Eckhard, Wurst Wolfgang, Zimmer Andreas, Fuchs Helmut, Gailus-Durner Valérie, Hrabe de Angelis Martin, Ehninger Dan

Abstract excerpt

Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the FDA-approved mTOR inhibitor rapamycin represented the first demonstration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granuloma

Share to Maze Learning

Share to Muscle Strength

Share to Platelet Count

Share to Psychomotor Performance

Share to Sirolimus

Share to Thyroid Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 23863708
DOI: 10.1172/JCI67674
PMCID: PMC3726163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin extends murine lifespan but has limited effects on aging.PMID 23863708Read ↗

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related DiseasesSemantic proximity Read ↗

Rapamycin extends maximal lifespan in cancer-prone mice.Semantic proximity Read ↗

Resveratrol and rapamycin: are they anti‐aging drugs?Semantic proximity Read ↗

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice.Semantic proximity Read ↗

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J MiceSemantic proximity Read ↗

A combination of the geroprotectors trametinib and rapamycin is more effective than either drug aloneSemantic proximity Read ↗

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous MiceSemantic proximity Read ↗

Biology of Healthy Aging and LongevitySemantic proximity Read ↗

Mouse Models to Disentangle the Hallmarks of Human AgingSemantic proximity Read ↗

Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?Semantic proximity Read ↗

Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by AgingSemantic proximity Read ↗

Functional and multi-omic aging rejuvenation with GLP-1R agonismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.