Article

<i>mtor</i> Haploinsufficiency Ameliorates Renal Cyst Formation in Adult Zebrafish <i>tmem67</i> Mutants

2019-12-20

Abstract excerpt

Although zebrafish embryos have been utilized to study ciliogenesis and to model polycystic kidney disease (PKD), adult zebrafish remain unexplored. Here, we report the generation and characterization of a zebrafish mutant of tmem67 , a homologue of the mammalian causative gene for Meckel syndrome type 3 (MKS3). Although a small population of homozygous embryos exhibited pronephric cysts, all mutants were able to...

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Literature Corpus work: af2165f4-a2c5-5980-bc58-122b56ad82c2
DOI: 10.1101/2019.12.20.883710

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