Article

Prognostic Biomarker MUC4 Mutations in Colon Adenocarcinoma Correlating with Tumor Microenvironment

2021-01-07

Abstract excerpt

<h4>Background: </h4> Immunotherapy is a new strategy for Colorectal cancer (CRC) treatment. Tumor mutation burden (TMB) may act as an emerging biomarker for predicting responses to immunotherapy. Nevertheless, no studies investigate if these gene mutations correlate to TMB and tumor-infiltrating immune cells. <h4>Methods: </h4>: Somatic mutation data for CRC samples were obtained from The Cancer Genome Atlas (TCG...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e06bfb3-9d2b-5bd8-81c9-d9adbaf98478
DOI: 10.21203/rs.3.rs-137615/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prognostic Biomarker MUC4 Mutations in Colon Adenocarcinoma Correlating with Tumor MicroenvironmentDOI 10.21203/rs.3.rs-137615/v1Read

MUC4 mutation correlates with tumor mutation burden and the immune microenvironment in colorectal cancerSemantic proximity Read

Mucin 4 mutation is associated with tumor mutation burden and promotes antitumor immunity in colon cancer patients.Semantic proximity Read

Exploration of the relationship between tumor mutation burden and immune infiltrates in colon adenocarcinoma.Semantic proximity Read

Exploration of the role of tumor mutation burden in clinical significance, immunotherapy response predictor and immune cell infiltration in colon cancerSemantic proximity Read

Correlations Between Tumor Mutation Burden and Immunocyte Infiltration and Their Prognostic Value in Colon CancerSemantic proximity Read

Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis.Semantic proximity Read

Characterizing and forecasting neoantigens-resulting from MUC mutations in COAD.Semantic proximity Read

Comprehensive Analysis of Subtype-Specific Molecular Characteristics of Colon Cancer: Specific Genes, Driver Genes, Signaling Pathways, and Immunotherapy ResponsesSemantic proximity Read

A MiRNA-based Signature is Associated With Tumor Mutational Burden in Colon AdenocarcinomaSemantic proximity Read

FAT4 Mutation is Related to Tumor Mutation Burden and Favorable Prognosis in Gastric CancerSemantic proximity Read

A Mutational Signature that Predicts Prognosis and Benefit of Immune Checkpoint Blockade in Colorectal CancerSemantic proximity Read

Construction and validation of a colon cancer prognostic model based on tumor mutation burden-related genes.Semantic proximity Read