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Article

Mucin 4 mutation is associated with tumor mutation burden and promotes antitumor immunity in colon cancer patients.

Aging - 14 Mar 2021

Peng Linglong, Li Yang, Gu Haitao, Xiang Ling, Xiong Yongfu, Wang Rong, Zhou He, Wang Jijian

Abstract excerpt

At present, immunotherapy is widely used for different mismatch repair (dMMR) or highly microsatellite instability (MSI-H) colorectal cancer patients, and tumor mutation burden (TMB) is a valuable independent predictor of response to immunotherapy. However, specific gene mutations and their relationship with TMB and tumor-infiltrating immune cells in colon cancer remains unclear. In the present study, we analyzed...

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Identifiers

PMID: 33714943
DOI: 10.18632/aging.202756
PMCID: PMC8034916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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