Targeting MYC Proteins for Tumor Therapy

Abstract excerpt

Targeting the function of MYC oncoproteins holds the promise of achieving conceptually new and effective anticancer therapies that can be applied to a broad range of tumors. The nature of the target however—a broadly, possibly universally acting transcription factor that has no enzymatic activity and is largely unstructured unless complexed with partner proteins—has so far defied the development of clinically appl...

Topics

Open a Topic to create a Post that cites this publication.

• CAR-T cell therapy research
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

b7a91f46-4672-5421-9663-eb4783def86e

DOI

10.1146/annurev-cancerbio-030518-055826