Article
The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers.
Genes - 21 Jul 2020
Watters Andrea K, Seltzer Emily S, MacKenzie Danny, Young Melody, Muratori Jonathan, Hussein Rama, Sodoma Andrej M, To Julie, Singh Manrose, Zhang Dong
Abstract excerpt
Breast Cancer 1 (BRCA1) gene is a well-characterized tumor suppressor gene, mutations of which are primarily found in women with breast and ovarian cancers. BRCA1-associated RING domain 1 (BARD1) gene has also been identified as an important tumor suppressor gene in breast, ovarian, and uterine cancers. Underscoring the functional significance of the BRCA1 and BARD1 interactions, prevalent mutations in the BRCA1...
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