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Article

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.

Open biology - 1 Oct 2021

Bunch Heeyoun, Jeong Jaehyeon, Kang Keunsoo, Jo Doo Sin, Cong Anh T Q, Kim Deukyeong, Kim Donguk, Cho Dong-Hyung, Lee You Mie, Chen Benjamin P C, Schellenberg Matthew J, Calderwood Stuart K

Abstract excerpt

RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans. Here, we report a novel function of the breast cancer 1 (BRCA1)-BRCA1-associated ring domain 1 (BARD1) complex in this process. We found that BRCA1 is phosphorylated at S1524 by the kinases ataxia-telangiectasia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34610268
DOI: 10.1098/rsob.210221
PMCID: PMC8492178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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