Article

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

2023-10-04

Abstract excerpt

Recently developed covalent inhibitors for RasG12C provide the first pharmacological tools to target mutant Ras-driven cancers. However, the rapid development of resistance to current clinical Ras G12C inhibitors is common. Presumably, a subpopulation of RasG12C-expressing cells adapt their signaling to evade these inhibitors and the mechanisms for this phenomenon are unclear due to the lack of tools that can meas...

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Literature Corpus work: 4de9a58f-3d31-5a30-8b1d-5e165c3ad98e
DOI: 10.1101/2023.10.02.560617

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