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Article

Mutant RAS Calms Stressed-Out Cancer Cells.

Developmental cell - 23 Jan 2017

Bryant Kirsten L, Der Channing J

Abstract excerpt

Mutant RAS-driven cancers are infamously resistant to chemotherapeutics. Reporting in Cell, Grabocka and Bar-Sagi (2016) demonstrate that when subjected to stress, mutant KRAS-dependent lipid production leads to upregulated stress granule formation. This confers not only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor niche.

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Identifiers

PMID: 28118599
DOI: 10.1016/j.devcel.2017.01.005
PMCID: PMC6484846

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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