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Article

The importance of Ras in drug resistance in cancer

26 Feb 2021

Abstract excerpt

In this review, we analyse the impact of oncogenic Ras mutations in mediating cancer drug resistance and the progress made in the abrogation of this resistance, through pharmacological targeting. At a physiological level, Ras is implicated in many cellular proliferation and survival pathways. However, mutations within this small GTPase can be responsible for the initiation of cancer, therapeutic resistance and...

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Identifiers

PMID: 33634485
DOI: 10.1111/bph.15420

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