Back to search

Article

Decitabine treatment demethylates vast majority of high-confidence differentially methylated regions in HCT-116 colorectal cancer cells

2020-08-04

Abstract excerpt

<h4>Background: </h4> Gene silencing by CpG island hypermethylation often plays a role in colorectal cancer (CRC) progression. Certain regions of the genome, called high confidence differentially-methylated regions (DMRs), are consistently hypermethylated across numerous patient samples. <h4>Methods: </h4>: In this study, we used bioinformatics and bisulfite PCR sequencing of HCT-116 cells to investigate methylat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
70453cf2-7aa9-5314-bee4-efb6c3f91579
DOI
10.12688/f1000research.20442.1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Decitabine treatment demethylates vast majority of high-confidence differentially methylated regions in HCT-116 colorectal cancer cellsDOI 10.12688/f1000research.20442.1
DNMT inhibitors increase methylation at subset of CpGs in colon, bladder, lymphoma, breast, and ovarian, cancer genomeSemantic proximity
Dissection of demethylation and toxicity induced gene expression changes after decitabine treatmentSemantic proximity
DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancersSemantic proximity
SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy responseSemantic proximity
CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathwaySemantic proximity
Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathwaysSemantic proximity
Unraveling <em>TNXB </em>Epigenetic Alterations through Genome wide DNA methylation and their Implications for Colorectal Cancer PathogenesisSemantic proximity
Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChipsSemantic proximity
DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancerSemantic proximity
A genome-wide DNA methylation study in colorectal carcinomaSemantic proximity
Decitabine, a new star in epigenetic therapy: the clinical application and biological mechanism in solid tumorsSemantic proximity
Analysis of Genomic DNA Methylation and Gene Transcription Modulation Induced by DNMT3A Deficiency in HEK293 CellsSemantic proximity
Select a neighboring publication to make it the new centre.