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Methylation-Based Therapies for Colorectal Cancer

24 Jun 2020

Abstract excerpt

Colorectal carcinogenesis (CRC) is caused by the gradual long-term accumulation of both genetic and epigenetic changes. Recently, epigenetic alterations have been included in the classification of the CRC molecular subtype, and this points out their prognostic impact. As epigenetic modifications are reversible, they may represent relevant therapeutic targets. DNA methylation, catalyzed by DNA methyltransferases...

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PMID: 32599894
DOI: 10.3390/cells9061540

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