Article
Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.
Cellular and molecular life sciences : CMLS - 1 Apr 2012
Alais Sandrine, Soto-Rifo Ricardo, Balter Vincent, Gruffat Henri, Manet Evelyne, Schaeffer Laurent, Darlix Jean Luc, Cimarelli Andrea, Raposo Graça, Ohlmann Théophile, Leblanc Pascal
Abstract excerpt
The cellular prion protein PrP(C)/CD230 is a GPI-anchor protein highly expressed in cells from the nervous and immune systems and well conserved among vertebrates. In the last decade, several studies suggested that PrP(C) displays antiviral properties by restricting the replication of different viruses, and in particular retroviruses such as murine leukemia virus (MuLV) and the human immunodeficiency virus type 1...
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