Article

Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Innate defences of the respiratory epithelium are the first barrier against incoming respiratory viruses. To understand the contribution of both basal (tonic) and induced interferon (IFN) to antiviral defences in a physiologically relevant system, we established air-liquid interface (ALI) cultures of primary human bronchial epithelium (HBE) and small airway epithelium (HSE). Via an organoid inte...

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Literature Corpus work: 3ab1c902-7f48-51b6-a5f2-6cba39283dcd
DOI: 10.64898/2025.12.10.693424

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