Article

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

2005-03-10

Abstract excerpt

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still controversial whether the MLL fusion protein is sufficient to induce acute leukemia without additional genetic alterations, although carcinogenesis in general is known to result from more than 1 genetic disorder accum...

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Literature Corpus work: 4d5a0a55-0ccc-5f8d-9882-0333f2dfb801
DOI: 10.1172/jci200522725

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