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Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

10 Mar 2005

Abstract excerpt

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still controversial whether the MLL fusion protein is sufficient to induce acute leukemia without additional genetic alterations, although carcinogenesis in general is known to result from more than 1 genetic disorder...

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PMID: 15761502
DOI: 10.1172/jci22725

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