Article

Engineered developmental niche enables predictive phenotypic screening in human dystrophic cardiomyopathy

2018-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Directed differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes typically produces cells with structural, functional, and biochemical properties that most closely resemble those present in the fetal heart. Here we establish an in vitro engineered developmental cardiac niche to produce matured hPSC-derived cardiomyocytes (hPSC-CMs) with enhanced sarcomere development, electr...

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Literature Corpus work: 2434c406-b01f-527f-9940-902dc6fd9d48
DOI: 10.1101/456301

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