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Article

Heterozygous Spink1 c.194+2T>C mutation promotes chronic pancreatitis after acute attack in mice.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Aug 2024

Liu Muyun, Ma Lizhe, An Wei, Yang Yaying, Liu Juncen, Jiang Hui, Yuan Jihang, Sun Xiaoru, Zhu Jingyi, Yan Maoyun, Wang Luowei, Li Zhaoshen, Liao Zhuan, Sun Chang

Abstract excerpt

BACKGROUND & AIMS: Mutations in genes, including serine protease inhibitor Kazal-type 1 (SPINK1), influence disease progression following sentinel acute pancreatitis event (SAPE) attacks. SPINK1 c.194+2T > C intron mutation is one of the main mutants of SPINK1，which leads to the impairment of SPINK1 function by causing skipping of exon 3. Research on the pathogenesis of SAPE attacks would contribute to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38763786
DOI: 10.1016/j.pan.2024.05.514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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