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Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria

16 Feb 2024

Abstract excerpt

Horizontal gene transfer (HGT) and gene duplication are often considered as separate mechanisms driving the evolution of new functions. However, the mobile genetic elements (MGEs) implicated in HGT can copy themselves, so positive selection on MGEs could drive gene duplications. Here, we use a combination of modeling and experimental evolution to examine this hypothesis and use long-read genome sequences of tens...

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PMID: 38365845
DOI: 10.1038/s41467-024-45638-9

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