Article
The joys and terrors of fast adaptation: new findings elucidate antibiotic resistance and natural selection.
Molecular microbiology - 1 Jan 2011
Roth John R
Abstract excerpt
Experiments of Pränting and Andersson demonstrate how bacteria adapt to the growth limitation caused by antibiotic resistance mutations. The process of adaptation relies on gene copy number changes that arise at high rates, including duplications (10(-4) per cell per generation), amplifications (10(-2) per cell per generation) and mutant copy loss (10(-2) per cell per division). Reversible increases in copy...
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