Article

Intrinsic and Acquired Drug Resistance to LSD1 Inhibitors in SCLC Occurs through a TEAD4 Driven Transcriptional State

2021-03-01

Abstract excerpt

<h4>Background: </h4> SCLC is a heterogeneous disease, consisting of intra-tumoral and inter-tumoral neuroendocrine (ASCL1/NEUROD1), mesenchymal-like, and YAP-driven transcriptional states. Lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors have recently been progressed to clinical trials in small cell lung cancer (SCLC) based on a promising pre-clinical anti-tumor activity. Potential clinical limitation of LSD...

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Literature Corpus work: 4d06499f-757d-5b06-b553-7fdf64dc7e47
DOI: 10.21203/rs.3.rs-249776/v1

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