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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

2024-07-30

Abstract excerpt

<h4>Introduction</h4> A hallmark of small cell lung cancer (SCLC) is its recalcitrance to therapy. While most SCLCs respond to frontline therapy, resistance inevitably develops. Identifying phenotypes potentiating chemoresistance and immune evasion is a crucial unmet need. Previous reports have linked upregulation of the DNA damage response (DDR) machinery to chemoresistance and immune evasion across cancers. How...

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Literature Corpus work
09433986-5395-5152-afdc-aee606c7ffd7
DOI
10.1101/2024.07.29.605595
Open publication

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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancerDOI 10.1101/2024.07.29.605595
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