Article

The presence and impact of reference bias on population genomic studies of prehistoric human populations

2018-12-06

Abstract excerpt

High quality reference genomes are an important resource in genomic research projects. A consequence is that DNA fragments carrying the reference allele will be more likely to map suc-cessfully, or receive higher quality scores. This reference bias can have effects on downstream population genomic analysis when heterozygous sites are falsely considered homozygous for the reference allele. In palaeogenomic studies...

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Literature Corpus work: 4cff2515-a84f-5eb2-88a7-8ea559eb4f86
DOI: 10.1101/487983

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