Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic benchmark of ancient DNA read mapping.

Briefings in bioinformatics - 2 Sept 2021

Oliva Adrien, Tobler Raymond, Cooper Alan, Llamas Bastien, Souilmi Yassine

Abstract excerpt

The current standard practice for assembling individual genomes involves mapping millions of short DNA sequences (also known as DNA 'reads') against a pre-constructed reference genome. Mapping vast amounts of short reads in a timely manner is a computationally challenging task that inevitably produces artefacts, including biases against alleles not found in the reference genome. This reference bias and other...

Topics

Join the communities discussing this publication.

Algorithms
Benchmarking
Computational Biology
DNA, Ancient
Genome, Human
Reproducibility of Results

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Alignment

Source

Identifiers

PMID: 33834210
DOI: 10.1093/bib/bbab076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic benchmark of ancient DNA read mapping.PMID 33834210Read ↗

Removing reference bias and improving indel calling in ancient DNA data analysis by mapping to a sequence variation graphSemantic proximity Read ↗

Improving ancient DNA read mapping against modern reference genomes.Semantic proximity Read ↗

Pre-processing of paleogenomes: Mitigating reference bias and postmortem damage in ancient genome dataSemantic proximity Read ↗

Estimating allele frequencies, ancestry proportions and genotype likelihoods in the presence of mapping bias.Semantic proximity Read ↗

BADGER: evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulationsSemantic proximity Read ↗

Competitive mapping allows to identify and exclude human DNA contamination in ancient faunal genomic datasetsSemantic proximity Read ↗

A curated dataset of modern and ancient high-coverage shotgun human genomesSemantic proximity Read ↗

The presence and impact of reference bias on population genomic studies of prehistoric human populationsSemantic proximity Read ↗

Computational challenges in the analysis of ancient DNA.Semantic proximity Read ↗

bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS).Semantic proximity Read ↗

Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study.Semantic proximity Read ↗

Evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.