Introducing the Y-chromosomal Ancestral-like Reference Sequence-Improving the Capture of Human Evolutionary Information.

Abstract excerpt

Reference sequences are essential for reproducible genetic analyses but are often chosen without regard to evolutionary relevance within the analyzed species. The human Y chromosome is widely used in evolutionary studies, yet current references represent evolutionarily young sequences, which can cause misleading variant calling. To address this issue, we constructed a Y-chromosomal ancestral-like reference...

Topics

• Chromosomes, Human, Y
• Humans
• Evolution, Molecular
• Animals
• Polymorphism, Single Nucleotide
• Phylogeny