Article

Introducing the Y chromosome ancestral reference sequence - Improving the capture of human evolutionary information

2025-05-07

Abstract excerpt

Reference sequences are essential for reproducible genetic analyses but are often chosen without regard to evolutionary relevance within the analyzed species. The human Y chromosome (chrY) is widely used in evolutionary studies, yet current references represent evolutionarily young sequences, which can lead to misleading variant calling. To address this issue, we constructed a Y-chromosomal ancestral-like referenc...

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Literature Corpus work: 1e6c70e3-b86a-52bc-827f-55d109628d2d
DOI: 10.1101/2025.05.07.652589

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