Article

Checkpoint adaptation in repair-deficient cells drives aneuploidy and resistance to genotoxic agents

2018-11-07

Abstract excerpt

Human cancers frequently harbour mutations in DNA repair genes, rendering the use of DNA damaging agents as an effective therapeutic intervention. As therapy-resistant cells often arise, it is important to better understand the molecular pathways that drive resistance in order to facilitate the eventual targeting of such processes. We employ repair-defective diploid yeast as a model to demonstrate that, in respons...

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Literature Corpus work: 4cfecd64-f5a2-5845-a601-7050d996489a
DOI: 10.1101/464685

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