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Article

A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response

26 Jan 2024

Abstract excerpt

Psoriasis vulgaris and other chronic inflammatory diseases improve markedly with therapeutic blockade of interleukin-23 (IL-23) signaling, but the genetic mechanisms underlying clinical responses remain poorly understood. Using single-cell transcriptomics, we profiled immune cells isolated from lesional psoriatic skin before and during IL-23 blockade. In clinically responsive patients, a psoriatic transcriptional...

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PMID: 38277466
DOI: 10.1126/sciimmunol.adi2848

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