Article

Physiological (TCR-like) regulated lentiviral vectors for the generation of improved CAR-T cells

2021-03-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chimeric antigen receptor (CAR) T cells directed against CD19 have achieved impressive outcomes for the treatment of relapsed/refractory B lineage lymphoid neoplasms. However, CAR-T therapy still has important limitations due to severe side effects and the lack of efficiency in 40-50% of the patients. Most CARs-T products are generated using retroviral vectors with strong prom...

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Literature Corpus work: 159af2a5-3cae-5ed1-8cb5-d9110a643d28
DOI: 10.1101/2021.03.17.21253300

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