A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor

Abstract excerpt

Vectors that facilitate the engineering of T cells that can better harness endogenous immunity and overcome suppressive barriers in the tumour microenvironment would help improve the safety and efficacy of T-cell therapies for more patients. Here we report the design, production and applicability, in T-cell engineering, of a lentiviral vector leveraging an antisense configuration and comprising a promoter driving...

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