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Regulation of CAR transgene expression to design semiautonomous CAR-T

15 Jun 2024

Abstract excerpt

Effective transgene expression is critical for genetically engineered cell therapy. Therefore, one of CAR-T cell therapy's critical areas of interest, both in registered products and next-generation approaches is the expression of transgenes. It turns out that various constitutive promoters used in clinical products may influence CAR-T cell antitumor effectiveness and impact the manufacturing process....

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PMID: 39184876
DOI: 10.1016/j.omton.2024.200833

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